Tree Frog Treks is a science facility that runs programs, camps, and classes for kids of all ages. I have a friend who lives in the Haight and we dropped our two boys off at the camp for a "rocket science" Kid's Play Night, and then the two of us were able to go out for dinner and dessert sans children. Awesome.
Math came home with wild stories about touching all sorts of cool reptiles, learned how the frog cycle works, and built a small rocket. Dinner, drinks, and a movie were also included.
You do need to register ahead, but if you're coming to SF and want to do some grownup time this might be the perfect way! Drop off is at 5:30, pick up is at 9.